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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CHEK1
All Species:
25.45
Human Site:
T348
Identified Species:
40
UniProt:
O14757
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O14757
NP_001107593.1
476
54420
T348
G
I
S
F
S
Q
P
T
C
P
D
H
M
L
L
Chimpanzee
Pan troglodytes
XP_001145968
476
54387
T348
G
I
S
F
S
Q
P
T
C
P
D
H
M
L
L
Rhesus Macaque
Macaca mulatta
XP_001111357
476
54432
T348
G
I
S
F
S
Q
P
T
C
P
D
H
M
L
L
Dog
Lupus familis
XP_852191
460
52810
T332
G
I
S
F
S
Q
P
T
C
P
D
H
M
L
L
Cat
Felis silvestris
Mouse
Mus musculus
O35280
476
54363
T348
G
I
S
F
S
Q
P
T
C
P
E
H
M
L
V
Rat
Rattus norvegicus
Q91ZN7
476
54410
T348
G
I
S
F
S
Q
P
T
C
P
D
H
M
L
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513209
476
53924
A348
G
I
S
F
S
Q
P
A
C
P
D
H
M
L
L
Chicken
Gallus gallus
Q8AYC9
476
53830
A348
G
I
S
F
S
Q
P
A
C
P
E
H
M
L
L
Frog
Xenopus laevis
Q6DE87
474
53957
A347
G
I
S
F
S
Q
P
A
C
P
D
N
M
L
L
Zebra Danio
Brachydanio rerio
NP_956487
410
46756
G299
T
Q
L
L
G
T
P
G
A
S
Q
S
P
W
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O61661
512
57815
Q360
K
E
D
G
G
D
R
Q
T
L
A
Q
E
A
R
Honey Bee
Apis mellifera
XP_623436
467
53927
T346
Q
V
Q
T
K
Q
F
T
Q
T
S
Q
Q
N
T
Nematode Worm
Caenorhab. elegans
Q9N3Z3
503
56917
L368
S
Q
T
N
S
N
L
L
Q
R
M
V
C
R
M
Sea Urchin
Strong. purpuratus
NP_001091925
468
52554
S348
H
S
D
N
M
L
L
S
S
Q
L
Q
C
T
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q84VQ3
439
49610
T309
E
K
K
E
E
Q
P
T
S
M
N
A
F
E
L
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
99.3
93.2
N.A.
93.2
94.3
N.A.
89.9
84.4
77.7
56.9
N.A.
46
45.5
32
57.9
Protein Similarity:
100
100
99.7
95.1
N.A.
97
97.2
N.A.
95.3
91.5
86.7
71
N.A.
62.8
63.8
48.7
73.3
P-Site Identity:
100
100
100
100
N.A.
86.6
93.3
N.A.
93.3
86.6
86.6
6.6
N.A.
0
13.3
6.6
0
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
93.3
93.3
93.3
6.6
N.A.
0
20
20
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
32.9
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
52.1
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
26.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
33.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
20
7
0
7
7
0
7
0
% A
% Cys:
0
0
0
0
0
0
0
0
60
0
0
0
14
0
0
% C
% Asp:
0
0
14
0
0
7
0
0
0
0
47
0
0
0
0
% D
% Glu:
7
7
0
7
7
0
0
0
0
0
14
0
7
7
0
% E
% Phe:
0
0
0
60
0
0
7
0
0
0
0
0
7
0
0
% F
% Gly:
60
0
0
7
14
0
0
7
0
0
0
0
0
0
0
% G
% His:
7
0
0
0
0
0
0
0
0
0
0
54
0
0
0
% H
% Ile:
0
60
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
7
7
7
0
7
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
7
7
0
7
14
7
0
7
7
0
0
60
54
% L
% Met:
0
0
0
0
7
0
0
0
0
7
7
0
60
0
7
% M
% Asn:
0
0
0
14
0
7
0
0
0
0
7
7
0
7
0
% N
% Pro:
0
0
0
0
0
0
74
0
0
60
0
0
7
0
7
% P
% Gln:
7
14
7
0
0
74
0
7
14
7
7
20
7
0
7
% Q
% Arg:
0
0
0
0
0
0
7
0
0
7
0
0
0
7
7
% R
% Ser:
7
7
60
0
67
0
0
7
14
7
7
7
0
0
0
% S
% Thr:
7
0
7
7
0
7
0
54
7
7
0
0
0
7
7
% T
% Val:
0
7
0
0
0
0
0
0
0
0
0
7
0
0
14
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
7
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _